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Saturday, September 12 • 2:45pm - 4:00pm
Mechanism of Action of Insomnia Medications: Implications for Clinical Practice

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Insomnia is the second most commonly encountered symptom in clinical medicine, reported by 80% of psychiatric patients. It is also one of the most challenging complaints in psychiatric practice, as it complicates the care of many mental illnesses. Although numerous hypnotic agents are available for insomnia management, they are predominantly agents with the same mechanism (ie, activation at the GABA-BZ receptor complex). Over the past few years, however, a variety of agents have been introduced with several more under development that possess novel mechanisms for the management of insomnia. These agents have introduced the possibility of enhanced safety and unique suitability for specific psychiatric populations. This session will review the basic sleep mechanisms and traditional GABA-ergic medications, as well as novel agents acting as melatonin, histamine, and orexin receptors. It will also present strategies for tailoring available pharmacologic agents to the patient’s clinical need to optimize clinical efficacy.


Speakers
avatar for Karl Doghramji, MD

Karl Doghramji, MD

Professor of Psychiatry, Neurology, and Medicine, Medical Director, Jefferson Sleep Disorders Center, Program Director, Fellowship in Sleep Medicine, Thomas Jefferson University, Philadelphia, PennsylvaniaKarl Doghramji, MD, is a Professor of Psychiatry, Neurology, and Medicine at... Read More →


Saturday September 12, 2015 2:45pm - 4:00pm PDT
28E

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