There is no evidence for the effectiveness of polypharmacy in the treatment of borderline personality disorder (BPD), yet clinical experience reveals that many patients with BPD often take 2 or more medications simultaneously. In addition to the lack of data to support clinical improvement from this multiple psychotropic medication approach, the use of polypharmacy has a much greater chance of inducing adverse effects and weight gain than it does in leading to clinical improvement. This session will review the value, as well as the limitations, of psychopharmacologic treatment in BPD in order to mitigate the current propensity toward polypharmacy.
