Psychiatric medications are often an important component of a patient’s treatment. Nevertheless, drug-drug interactions (STET) and drug-gene interactions can profoundly alter the response to a drug regimen with clinical outcomes ranging from increased efficacy or loss of efficacy to clinically meaningful or life-threatening adverse effects. This session will review the growth in knowledge of DDIs and DGIs that have occurred over the past 20 years. Dr. Preskorn will provide practical tips on how to integrate these concepts into everyday practice.