Our population is aging rapidly, and memory loss is the most common complaint in individuals 65 years of age and older. Whereas we may have once been resigned to believe that cognitive impairment was an inevitable part of life, data now suggest that appropriate assessment and intervention can protect brain health in our older patients. In this session, Dr. Small will demonstrate how the latest evidence can be translated into practical strategies for diagnosing and treating age-related cognitive decline, including mood disorders that often accompany memory impairment. In addition to highlighting the recent research in this area, Dr. Small will discuss treatments and lifestyle strategies that protect brain health in patients of all ages.